Page 15 - 2025年10月號
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救助之道在基因中 每 1.000 名台灣男性中, 劉人鳳
may enable him to avoid the tragedies that happened
(Gene Jen-Feng Liu)
THE SPECIALIST ఱϞ 1 ɛ੭Ϟɓ၇ਿΪᜊembers.
to other family m
台灣中壢和平扶輪社
ɓЗ̨ᝄҧቃٟࡰп˼ٙषɛ
Saving lives is ମd̴ึኬߧːЄጐၳᄻ 遺傳學家與胸腔科醫師
One in every 1,000 Taiwanese men possesses
̘ܠϽਿΪᏨٙूஈ
يfவ၇ઋر̙ঐኬߧจ
a genetic variant that causes the heart muscle to
in his genes ̮ٙːᛔস။fҢࡁ೯ତdவ၇ਿΪ߉ᜊৎ๕
accumulate waste products. This condition can
cause unexpected heart failure. We discovered that
ɽߒ 800 ϋۃʕɽٙɓࡈࡈf˼ٙεܝ
this genetic mutation originated in a man from
A Taiwanese Rotarian helps his patients ˾ཁ̨̺ᝄձԭݲՉ˼ήਜdேᙳ੭வ၇ਿΪf
mainland China about 800 years ago. Many of his
ί 一次同學會上,我遇到了一位朋友,˼ ɓ͇Ңࡁᆽ֛ə੭Ϊ٫dఱ̙˸ৰ˼ࡁٙːЄ
consider the benefits of genetic testing
descendants, who are spread across Taiwan and
̨݊ͭᝄɽኪʱɿᔼኪӺהϼࢪf
elsewhere in Asia, are carrying this gene. Once
D ҢʘۃԫխіᔼኪʈЪdШ˼ོᎸҢ 我們正處於「基因時代」的開端。Ңڀࣛගၾద
ʕٙᄻيdԣ˟˼ࡁί৵זؒאԃᒄԫʕᾄϥf
we identify a person who carries it, we can clean
out their heart muscle and prevent sudden deaths
uring a class reunion, I ran into a friend
ࠠڏࣧdҸᛘ፲ෂኪfҢ2019ϋϽɝ၂ɻफf
who directed the Institute of Molecular
during marathons or sports events.
Medicine at National Taiwan University.
ʿҧቃٟʱԮνОਗ਼ਿΪӺᏐ͜ତྼ͛ݺ
基因型是個人的基因藍圖,ڌତۨۆ݊༈ᔝྡٙ
I had been working in respiratory medi-
We are on the cusp of the “genetic era.” I spend
cine, but he encouraged me to go back
time speaking to the media and Rotary clubs, shar-
ՈяତfҢ༶͜வՇ٫Ըܸኬशषٙൢᓙeط ٙྼԷfԷνdί̨ᝄdਿΪ࿁ᖹيٙᅂᚤڢ੬
to school and study genetics. I enrolled in a master’s ࠠࠅdΪމεɛ੭ϞݔԬਿΪᜊମdኬߧ˼ࡁ
ing examples of how we can apply genetic studies
ᐕձཫԣfԷνdϞЗϋჀٙषɛѓൡҢd˼
to real-life situations. For example, the effect of
program in 2019. ࿁ᖹيཀઽdϾவԬᖹيٙਓЪ̙͜ঐܼ̍ߧն
ૄεɛϥ˴ਗএᆯॎfவఱ݊ڌତۨfމ your genes on medicines is important in Taiwan
because many people have certain genetic vari-
A person’s genotype is their genetic blueprint, ٙͤᇮᆖဴfତίdҢࡁ̙˸Ⴠᕦ˲˸Υଣᄆࣸ
əҬ̈षΪdҢࡁආБəਿΪᏨdԨ೯ତ༈ष
and their phenotype is the manifestation of that blue- ᐏ՟வԬਿΪ༟ৃf
ants that make them allergic to medications, with
ɛᆽྼπίၾ˴ਗএᆯᗫٙਿΪᜊମfҢึܔ
print. I use the two to guide the diagnosis, treatment, side effects that can include life-threatening skin
ulcers. Now we can discover that genetic informa-
and prevention of diseases. For example, a young 許多人可能會將基因醫學視為嫌惡資訊 ķķ ν؈
ᙄ˼ତίఱකછՓАᏀdԨ֛ಂ൙П˴ਗএٙ
patient tells me that many of his family members died Gene Jen-Feng tion easily and at an affordable price.
from ruptured aortic aneurysms. That would be the Ы੭ϞߧषਿΪᜊମdЫྐྵᗴʔٝઋfҢତίᐄ
ًرfவԬણ݄אঐᜫ˼ᒒе೯͛Չ˼ɛٙ Liu
phenotype. To find out the cause, we run genetic test- Rotary Club of Many people might have viewed genetic medicine
ేᄌf
ɓൢהd༊ྡਗ਼ɛࡁٙซجᔷᜊމһ͍ࠦٙซجf
ing and realize the patient does have a genetic variant Chungli Peace, as something ominous — if you carry a disease-
Photograph by Ed Zirkle
associated with aortic aneurysms. I would advise Taiwan causing genetic variation, you’d rather not know.
him to start managing his blood pressure now and Geneticist and I’m now operating a clinic where I try to change
regularly assess the aorta’s condition. These measures pulmonologist people’s thinking to something more positive. 13
臺灣扶輪 2025.10
10 ROTARY OCTOBER 2025 Photograph by Ed Zirkle
oct25-B-Specialist.indd 10 8/26/25 18:20