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救助之道在基因中                                    每 1.000 名台灣男性中,                 劉人鳳
                                                                   may enable him to avoid the tragedies that happened
                                                                                    (Gene Jen-Feng Liu)
                     THE SPECIALIST                       ఱϞ 1 ɛ੭Ϟɓ၇ਿΪᜊembers.
                                                                   to other family m
                                                                                     台灣中壢和平扶輪社
              ɓЗ̨ᝄҧቃٟࡰ՘п˼ٙषɛ
            Saving lives is                               ମd̴ึኬߧːЄጐၳᄻ               遺傳學家與胸腔科醫師
                                                                   One in every 1,000 Taiwanese men possesses
                  ̘ܠϽਿΪᏨ಻ٙूஈ
                                                          يfவ၇ઋر̙ঐኬߧจ
                                                                   a genetic variant that causes the heart muscle to
              in his genes                                ̮ٙːᛔস။fҢࡁ೯ତdவ၇ਿΪ߉ᜊৎ๕׵
                                                                   accumulate waste products. This condition can
                                                                   cause unexpected heart failure. We discovered that
                                                          ɽߒ 800 ϋۃʕ਷ɽ௔ٙɓࡈࡈ᜗f˼ٙ஢εܝ
                                                                   this genetic mutation originated in a man from
           A Taiwanese Rotarian helps his patients        ˾ཁ̨̺ᝄձԭݲՉ˼ήਜdேᙳ੭வ၇ਿΪf
                                                                   mainland China about 800 years ago. Many of his
       ί       一次同學會上,我遇到了一位朋友,˼                          ɓ͇Ңࡁᆽ֛ə੭Ϊ٫dఱ̙˸૶ৰ˼ࡁٙːЄ
            consider the benefits of genetic testing
                                                                   descendants, who are spread across Taiwan and
               ݊਷̨ͭᝄɽኪʱɿᔼኪ޼Ӻהϼࢪf
                                                                   elsewhere in Asia, are carrying this gene. Once
       D       Ңʘۃ੽ԫխіᔼኪʈЪdШ˼ོᎸҢ                          我們正處於「基因時代」的開端。Ңڀࣛගၾద
                                                          ʕٙᄻيdԣ˟˼ࡁί৵זؒא᜗ԃᒄԫʕᾄϥf
                                                                   we identify a person who carries it, we can clean
                                                                   out their heart muscle and prevent sudden deaths
                  uring a class reunion, I ran into a friend
       ࠠڏࣧ෤dҸᛘ፲ෂኪfҢ׵2019ϋϽɝ၂ɻफf
                  who directed the Institute of Molecular
                                                                   during marathons or sports events.
                  Medicine at National Taiwan University.
                                                          ᜗ʿҧቃٟʱԮνОਗ਼ਿΪ޼ӺᏐ͜׵ତྼ͛ݺ
       基因型是個人的基因藍圖,ڌତۨۆ݊༈ᔝྡٙ
                  I had been working in respiratory medi-
                                                                   We are on the cusp of the “genetic era.” I spend
                  cine, but he encouraged me to go back
                                                                   time speaking to the media and Rotary clubs, shar-
       Ո᜗яତfҢ༶͜வՇ٫Ըܸኬशषٙൢᓙeط                              ٙྼԷfԷνdί̨ᝄdਿΪ࿁ᖹيٙᅂᚤڢ੬
       to school and study genetics. I enrolled in a master’s   ࠠࠅdΪމ஢εɛ੭ϞݔԬਿΪᜊମdኬߧ˼ࡁ
                                                                   ing examples of how we can apply genetic studies
       ᐕձཫԣfԷνdϞЗϋჀٙषɛѓൡҢd˼࢕
                                                                   to real-life situations. For example, the effect of
       program in 2019.                                   ࿁ᖹيཀઽdϾவԬᖹيٙਓЪ̙͜ঐܼ̍ߧն
       ૄ஢εɛϥ׵˴ਗএᆯॎ൓fவఱ݊ڌତۨfމ                                       your genes on medicines is important in Taiwan
                                                                   because many people have certain genetic vari-
       A person’s genotype is their genetic blueprint,    ٙͤᇮᆖဴfତίdҢࡁ̙˸Ⴠᕦ˲˸Υଣᄆࣸ
       əҬ̈षΪdҢࡁආБəਿΪᏨ಻dԨ೯ତ༈ष
       and their phenotype is the manifestation of that blue-  ᐏ՟வԬਿΪ༟ৃf
                                                                   ants that make them allergic to medications, with
       ɛᆽྼπίၾ˴ਗএᆯ޴ᗫٙਿΪᜊମfҢึܔ
       print. I use the two to guide the diagnosis, treatment,     side effects that can include life-threatening skin
                                                                   ulcers. Now we can discover that genetic informa-
       and prevention of diseases. For example, a young   許多人可能會將基因醫學視為嫌惡資訊 ķķ ν؈
       ᙄ˼ତίఱක֐છՓАᏀdԨ֛ಂ൙П˴ਗএٙ
       patient tells me that many of his family members died   Gene Jen-Feng   tion easily and at an affordable price.
       from ruptured aortic aneurysms. That would be the   Ы੭ϞߧषਿΪᜊମdЫྐྵᗴʔٝઋfҢତί຾ᐄ
       ًرfவԬણ݄א஢ঐᜫ˼ᒒе೯͛Չ˼࢕ɛٙ Liu
       phenotype. To find out the cause, we run genetic test-  Rotary Club of   Many people might have viewed genetic medicine
       ేᄌf
                                                          ɓ࢕ൢהd༊ྡਗ਼ɛࡁٙซجᔷᜊމһ͍ࠦٙซجf
       ing and realize the patient does have a genetic variant   Chungli Peace,   as something ominous — if you carry a disease-
                                                                                        Photograph by Ed Zirkle
       associated with aortic aneurysms. I would advise   Taiwan   causing genetic variation, you’d rather not know.
       him to start managing his blood pressure now and   Geneticist and   I’m now operating a clinic where I try to change
       regularly assess the aorta’s condition. These measures   pulmonologist  people’s thinking to something more positive.  13
                                                                                       臺灣扶輪 2025.10
       10  ROTARY  OCTOBER 2025                                                             Photograph by Ed Zirkle
  oct25-B-Specialist.indd   10                                                                              8/26/25   18:20
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